The current clinical standards for infected chronic wounds are oral and topical antibiotics. These strategies are problematic because antibiotic resistance can occur with prolonged use. As an alternative to clinical methods, essential oils show promise in preventing bacterial growth. Specifically, 1,8-cineole-an active component in eucalyptus oil-exhibits antifungal, anti-inflammatory, and antibacterial properties. Applying 1,8-cineole directly onto a wound is challenging, however, due to its volatile nature. To combat this issue, plasma-enhanced chemical vapor deposition (PECVD) has been established as a method to deposit a stable 1,8-cineole-derived film on model surfaces (e.g., glass and electrospun polystyrene nanofibers). The current study represents an extension of previous work, where both pulsed and continuous 1,8-cineole plasmas were used to deposit a 1,8-cineole-derived film on two commercially available wound dressings. Three surface analyses were conducted to characterize the plasma-modified dressings. First, water contact angle goniometry data demonstrated a decrease in hydrofiber wettability after treatment. Through scanning electron spectroscopy, the surface morphology of both materials did not change upon treatment. When comparing pulsed and continuous treatments, deconvolution of high-resolution C1s x-ray photoelectron spectra showed no differences in functional group retention. Importantly, the chemical compositions of treated wound dressings were different compared to untreated materials. Overall, this work seeks to elucidate how different PECVD parameters affect the surface properties of wound dressings. Understanding these parameters represents a key step toward developing alternative chronic wound therapies.

中文翻译：

---

使用 1,8-桉树脑等离子体进行脉冲和连续沉积来改性市售伤口敷料材料。

目前感染慢性伤口的临床标准是口服和外用抗生素。这些策略存在问题，因为长期使用可能会出现抗生素耐药性。作为临床方法的替代方案，精油在防止细菌生长方面显示出前景。具体来说，1,8-桉树脑（桉树油中的一种活性成分）具有抗真菌、抗炎和抗菌特性。然而，由于其挥发性，将 1,8-桉树脑直接涂抹到伤口上具有挑战性。为了解决这个问题，等离子体增强化学气相沉积 (PECVD) 已被确立为一种在模型表面（例如玻璃和电纺聚苯乙烯纳米纤维）上沉积稳定的 1,8-桉树脑衍生薄膜的方法。目前的研究是先前工作的延伸，其中使用脉冲和连续 1,8-桉树脑等离子体在两种市售伤口敷料上沉积 1,8-桉树脑衍生薄膜。进行了三种表面分析来表征等离子体改性敷料。首先，水接触角测角数据表明处理后水纤维润湿性下降。通过扫描电子能谱，两种材料的表面形貌在处理后都没有改变。当比较脉冲处理和连续处理时，高分辨率 C1s X 射线光电子能谱的反卷积显示官能团保留没有差异。重要的是，经过处理的伤口敷料的化学成分与未经处理的材料不同。总的来说，这项工作旨在阐明不同的 PECVD 参数如何影响伤口敷料的表面特性。了解这些参数是开发替代性慢性伤口疗法的关键一步。