Fluoroquinolones (FQ), commonly prescribed antibiotics, may trigger aortic and carotid dissections. We report three successive cases of visceral artery dissection: one patient with celiac trunk dissection and two with dissection of the superior mesenteric artery. These events occurred up to 4 months after 7 to 14 days of FQ treatment (2 cases of ofloxacin, 1 of norfloxacin). There was no other apparent cause of dissection. These dissections were isolated, apart from a minimal aortic dissection separate from the visceral arterial dissection in one case. A case series cannot certify the relationship between dissection and FQ, but it can be hypothesized. The association between fluoroquinolone use and higher occurrence of aneurysm and dissection remains discussed in aortic syndrome. The potential link between FQ and visceral artery dissection is even less described but should be reported in the absence of previous cases in the literature. The pathophysiological theory is the induction of overexpression of some matrix metalloproteinases and a decrease of their inhibitors, provoking a dysregulation in collagen synthesis and degradation of the extracellular matrix.

中文翻译：

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内脏动脉解剖前使用氟喹诺酮：病例系列。

氟喹诺酮类药物 (FQ) 是常用的抗生素，可能会引发主动脉和颈动脉夹层。我们报告了三起连续的内脏动脉夹层病例：一名患者患有腹腔干夹层，两名患者患有肠系膜上动脉夹层。这些事件发生在 FQ 治疗 7 至 14 天后长达 4 个月（2 例氧氟沙星，1 例诺氟沙星）。没有其他明显的解剖原因。这些夹层是孤立的，除了一例中与内脏动脉夹层分开的最小主动脉夹层之外。病例系列无法证明解剖与 FQ 之间的关系，但可以进行假设。在主动脉综合征中，氟喹诺酮类药物的使用与动脉瘤和夹层发生率较高之间的关系仍有待讨论。FQ 和内脏动脉夹层之间的潜在联系甚至更少被描述，但在文献中缺乏先前病例的情况下应该报告。病理生理学理论是诱导某些基质金属蛋白酶的过度表达及其抑制剂的减少，引起胶原蛋白合成和细胞外基质降解的失调。