In this study, we explored the in vivo effects of Ocimum gratissimum aqueous extracts (OGE) on colorectal cancer (CRC) development provoked by azoxymethane/dextran sodium sulfate (AOM/DSS). The results showed a significant reduction in the tumor load and tumor number for the OGEH group that received continued administration of OGE compared to the AOM/DSS group, with p-values of <0.01, but this was not observed in the OGEHs group that received separated administration of OGE. All groups except the control group exhibited aberrant crypt foci (ACF) and adenocarcinoma of lesion pathology in colon, and both conditions were significantly reduced in the OGEH group (p<0.01) as compared to the AOM/DSS group. Subsequent investigation into whether OGE exhibits eliminative effects on DSS-induced severe colitis (SC) in mice showed that the disease activity index score was significantly reduced in the OGE-treated groups (p<0.01), also colon colitis histological score was reversed. These data suggest that OGE may be potentially effective in preventing CRC when administered throughout the promotional stages of carcinogenesis by inhibiting inflammatory SC.

中文翻译：

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罗勒水提取物可减轻小鼠结肠炎并预防 AOM/DSS 诱导的结直肠癌。

在这项研究中，我们探讨了罗勒水提取物 (OGE) 对氧化偶氮甲烷/葡聚糖硫酸钠 (AOM/DSS) 引起的结直肠癌 (CRC) 发展的体内影响。结果显示，与AOM/DSS组相比，持续给予OGE的OGEH组肿瘤负荷和肿瘤数量显着减少，p值<0.01，但在接受OGE治疗的OGEH组中没有观察到这一点。 OGE 的单独管理。除对照组外，所有组均表现出异常隐窝病灶（ACF）和结肠病变病理学腺癌，且与 AOM/DSS 组相比，OGEH 组这两种情况均显着减轻（p<0.01）。随后对OGE是否对DSS诱导的小鼠严重结肠炎（SC）具有消除作用的研究表明，OGE治疗组的疾病活动指数评分显着降低（p<0.01），并且结肠炎组织学评分也发生逆转。这些数据表明，OGE 在整个致癌促进阶段通过抑制炎症 SC 可能有效预防 CRC。