RORγt⁺ group 3 innate lymphoid cells (ILC3s), the innate counterpart of Th17 cells, are enriched in the mucosal area and lymphoid tissues. ILC3s interact with a variety of cells through their effector molecules and play an important role in the host defense against a spectrum of infections. Recent studies suggest that the extensive crosstalk between ILC3s and adaptive immune cells, especially T cells, is essential for maintaining tissue homeostasis. Here we discuss recent advances in the crosstalk between ILC3s and adaptive immune responses in multiple tissues and diseases. Understanding how ILC3s engage with adaptive immune cells will enhance our comprehension of diseases and facilitate the identification of novel therapeutic targets.

中文翻译：

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ILC3 与疾病中的适应性免疫之间的串扰

RORγt ⁺ 3 组先天淋巴细胞 (ILC3) 是 Th17 细胞的先天对应物，富含于粘膜区域和淋巴组织。ILC3 通过其效应分子与多种细胞相互作用，并在宿主防御一系列感染中发挥重要作用。最近的研究表明，ILC3 与适应性免疫细胞（尤其是 T 细胞）之间的广泛串扰对于维持组织稳态至关重要。在这里，我们讨论 ILC3 与多种组织和疾病中适应性免疫反应之间的串扰的最新进展。了解 ILC3 如何与适应性免疫细胞结合将增强我们对疾病的理解，并有助于识别新的治疗靶点。