Multiciliated cells (MCCS) form bundles of cilia and their activities are essential for the proper development and physiology of many organ systems. Not surprisingly, defects in MCCs have profound consequences and are associated with numerous disease states. Here, we discuss the current understanding of MCC formation, with a special focus on the genetic and molecular mechanisms of MCC fate choice and differentiation. Furthermore, we cast a spotlight on the use of zebrafish to study MCC ontogeny and several recent advances made in understanding MCCs using this vertebrate model to delineate mechanisms of MCC emergence in the developing kidney.

中文翻译：

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多纤毛细胞发育的遗传机制：从斑马鱼和其他模型的命运选择到分化

多纤毛细胞 (MCCS) 形成纤毛束，其活动对于许多器官系统的正常发育和生理机能至关重要。毫不奇怪，MCC 的缺陷会产生深远的后果，并与多种疾病状态相关。在这里，我们讨论目前对 MCC 形成的理解，特别关注 MCC 命运选择和分化的遗传和分子机制。此外，我们重点关注使用斑马鱼研究 MCC 个体发育，以及使用这种脊椎动物模型来描述发育中肾脏中 MCC 出现机制在理解 MCC 方面取得的一些最新进展。