Prunellae Spica (PS), derived from the dried fruit spikes of Prunella vulgaris L., is a traditional Chinese medicinal herb. Our previous studies found that PVE30, a water-extracting ethanol-precipitating “glycoprotein” macromolecule of PS, was a potential anti-herpes simplex virus (HSV) candidate. However, due to the complex structure and diverse bioactivity of the “glycoprotein”, ensuring its quality consistency across different batches of PVE30 becomes particularly challenging. This poses a significant hurdle for new drug development based on PVE30.

中文翻译：

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多指标测定结合层次聚类分析评价夏枯草抗HSV“糖蛋白”大分子PVE30的质量一致性

夏枯草（Prunellae Spica，PS）为夏枯草科植物夏枯草（ Prunella vulgaris L.）的干燥果穗，为传统中药材。我们之前的研究发现，PVE30（一种水提取乙醇沉淀的 PS“糖蛋白”大分子）是潜在的抗单纯疱疹病毒（HSV）候选药物。然而，由于“糖蛋白”的复杂结构和多样化的生物活性，确保不同批次的 PVE30 的质量一致性变得尤其具有挑战性。这对基于 PVE30 的新药开发构成了重大障碍。