Introduction

Despite the increased prevalence of comorbid attention deficit hyperactivity disorder (ADHD) in children with myotonic dystrophy type 1, the effects of methylphenidate treatment on associated cognitive deficits in this population is not yet investigated. Case: We describe a case study of an eleven-year-old male patient with myotonic dystrophy type 1 and comorbid ADHD that was treated with methylphenidate in a twice daily regime (0.60 mg/kg/day). Positive effects on learning and cognition were reported by the parents and teachers. No negative side effects were reported. Sequential neuropsychological assessments before and 45 minutes after methylphenidate intake were conducted to quantify the cognitive effects of methylphenidate treatment. Significant improvements in regulation of attention were behaviorally observed and were quantified using eye tracking technology. Conclusion: We conclude that methylphenidate may be an effective treatment for ADHD-related cognitive deficits and learning difficulties in children with myotonic dystrophy type 1 which merits further research.

中文翻译：

---

哌醋甲酯治疗儿童 1 型强直性肌营养不良症和共病注意力缺陷多动障碍的疗效：使用眼动追踪评估的病例报告

介绍

尽管1型强直性肌营养不良儿童中合并注意力缺陷多动障碍（ADHD）的患病率有所增加，但哌醋甲酯治疗对该人群相关认知缺陷的影响尚未得到研究。病例：我们描述了一名患有 1 型强直性肌营养不良并合并 ADHD 的 11 岁男性患者的案例研究，该患者接受每日两次哌甲酯治疗（0.60 mg/kg/天）。家长和老师报告了对学习和认知的积极影响。没有报告负面影响。在服用哌醋甲酯之前和之后 45 分钟进行连续的神经心理学评估，以量化哌醋甲酯治疗的认知效果。通过行为观察并使用眼动追踪技术对注意力调节的显着改善进行了量化。结论：我们的结论是，哌醋甲酯可能是治疗 1 型强直性肌营养不良儿童 ADHD 相关认知缺陷和学习困难的有效方法，值得进一步研究。