Background

The reasons for the etiology of premature ventricular contractions (PVCs) are not specifically known. Many patients are resistant to medical treatment, and a factor that would predict response to medical treatment cannot be identified. This study aims to investigate if a high catecholamine level results in polymorphic PVC.

Methods

This study was obtained by prospective data registry analysis. A total of 100 patients, 50 from the PVC group, and 50 from the control group have been evaluated. The participants who were included in the patient group had a polymorphic PVC of 5% or more in their 24-h Holter evaluations. Metanephrine showing the level of adrenaline and normetanephrine, showing the level of noradrenaline levels have been measured from these urine samples.

Result

There was no difference between the two groups in terms of biochemical and essential characteristics. Normetanephrine level has been significantly higher in the PVC group compared to the control group (323.9 ± 208.9 μg to 129.25 ± 67.88 μg; p < 0.001). Similarly, metanephrine level has also been higher in the PVC group (124.75 ± 82.43 μg to 52.615 ± 36,54 μg; p < 0.001). A positive and moderate correlation has been identified between the number and ratio of PVC and the metanephrine and normetanephrine levels.

Conclusion

In this study, we found that the catecholamine levels were higher in the polymorphic PVC group than in the healthy volunteers. Also, an increase in the number and rate of PVC has been observed as the catecholamine levels increased.

Clinical Trial Registration

Urine Levels of Metanephrine and Normetanephrine in Patients With Frequent PVC; ClinicalTrials.gov number NCT03447002

中文翻译：

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儿茶酚胺合成过多与多形性室性早搏之间的关联

背景

室性早搏（PVC）的病因尚不清楚。许多患者对药物治疗有抵抗力，并且无法确定预测药物治疗反应的因素。本研究旨在调查高儿茶酚胺水平是否会导致多晶型 PVC。

方法

这项研究是通过前瞻性数据登记分析获得的。总共有 100 名患者接受了评估，其中 50 名来自 PVC 组，50 名来自对照组。患者组中的参与者在 24 小时动态心电图评估中的多态性 PVC 为 5% 或更高。变肾上腺素显示肾上腺素水平，去甲肾上腺素显示已从这些尿液样本中测量出去甲肾上腺素水平。

结果

两组之间的生化和基本特征没有差异。与对照组相比，PVC 组的去甲变肾上腺素水平显着升高（323.9 ± 208.9 μg 至 129.25 ± 67.88 μg；p  < 0.001）。同样，PVC 组的变肾上腺素水平也较高（124.75 ± 82.43 μg 至 52.615 ± 36,54 μg；p < 0.001）。已发现 PVC 的数量和比例与变肾上腺素和去甲变肾上腺素水平之间存在正相关和中度相关性。

结论

在这项研究中，我们发现多晶型 PVC 组的儿茶酚胺水平高于健康志愿者。此外，随着儿茶酚胺水平的增加，PVC 的数量和比率也有所增加。

临床试验注册

频繁 PVC 患者的尿液中变肾上腺素和去甲变肾上腺素水平；ClinicalTrials.gov编号NCT03447002