N-(3-Amino-4-methylphenyl)benzamide is an intermediate product for the production of several medicines. Microreactor technology is a new concept for the continuous synthesis of chemicals. The computational fluid dynamics method was used to simulate the flow synthesis of N-(3-amino-4-methylphenyl)benzamide. There was good agreement between experimental data and modeling outputs. The effect of operating parameters such as temperature and residence time on system performance was investigated. The results revealed that an increase in temperature from 30 to 70 °C led to the enhancement of N-(3-amino-4-methylphenyl)benzamide production from about 42 to 76 % at a residence time of 420 s. It was found that the residence time and temperature have the largest influence on N-(3-amino-4-methylphenyl)benzamide production. Byproduct production was also increased by increasing the temperature and residence time.

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微反应器中 N-(3-氨基-4-甲基苯基)苯甲酰胺合成的建模与模拟

N- (3-氨基-4-甲基苯基)苯甲酰胺是用于生产多种药物的中间产品。微反应器技术是化学品连续合成的新概念。采用计算流体力学方法模拟N- (3-氨基-4-甲基苯基)苯甲酰胺的流动合成。实验数据和建模输出之间有很好的一致性。研究了温度和停留时间等操作参数对系统性能的影响。结果表明，温度从 30°C 升高到 70°C 导致N- (3-氨基-4-甲基苯基)苯甲酰胺产量在 420 s 的停留时间下从约 42% 增加到 76%。结果发现，停留时间和温度对N- (3-氨基-4-甲基苯基)苯甲酰胺产量影响最大。通过增加温度和停留时间也增加了副产物产量。