Purpose of Review

This review aims to elucidate the multifaceted role of the tumor suppressor protein p53 in the context of HIV infection. We explore how p53, a pivotal regulator of cellular processes, interacts with various facets of the HIV life cycle. Understanding these interactions could provide valuable insights into potential therapeutic interventions and the broader implications of p53 in viral infections.

Recent Findings

Recent research has unveiled a complex interplay between p53 and HIV. Several reports have highlighted the involvement of p53 in restricting the replication of HIV within both immune and nonimmune cells. Various mechanisms have been suggested to unveil how p53 enforces this restriction on HIV replication. However, HIV has developed strategies to manipulate p53, benefiting its replication and evading host defenses.

Summary

In summary, p53 plays a multifaceted role in HIV infection, impacting viral replication and disease progression. Recent findings underscore the importance of understanding the intricate interactions between p53 and HIV for the development of innovative therapeutic approaches. Manipulating p53 pathways may offer potential avenues to suppress viral replication and ameliorate immune dysfunction, ultimately contributing to the management of HIV/AIDS. Further research is warranted to fully exploit the therapeutic potential of p53 in the context of HIV infection.

中文翻译：

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p53 在 HIV 感染中的作用

审查目的

本综述旨在阐明肿瘤抑制蛋白 p53 在 HIV 感染中的多方面作用。我们探索细胞过程的关键调节因子 p53 如何与 HIV 生命周期的各个方面相互作用。了解这些相互作用可以为潜在的治疗干预措施以及 p53 在病毒感染中的更广泛影响提供有价值的见解。

最近的发现

最近的研究揭示了 p53 和 HIV 之间复杂的相互作用。一些报告强调了 p53 参与限制免疫细胞和非免疫细胞内 HIV 的复制。人们提出了各种机制来揭示 p53 如何对 HIV 复制实施这种限制。然而，HIV 已经开发出操纵 p53 的策略，有利于其复制并逃避宿主防御。

概括

总之，p53 在 HIV 感染中发挥多方面的作用，影响病毒复制和疾病进展。最近的研究结果强调了了解 p53 和 HIV 之间复杂的相互作用对于开发创新治疗方法的重要性。操纵 p53 通路可能提供抑制病毒复制和改善免疫功能障碍的潜在途径，最终有助于艾滋病毒/艾滋病的管理。需要进一步的研究来充分利用 p53 在 HIV 感染中的治疗潜力。