The discovery and utilization of natural products derived from endophytic microorganisms have garnered significant attention in pharmaceutical research. While remarkable progress has been made in this field each year, the absence of dedicated open-access databases for endophytic microorganism natural products research is evident. To address the increasing demand for mining and sharing of data resources related to endophytic microorganism natural products, this study introduces EMNPD, a comprehensive endophytic microorganism natural products database comprising manually curated data. Currently, EMNPD offers 6632 natural products from 1017 endophytic microorganisms, targeting 1286 entities (including 94 proteins, 282 cell lines, and 910 species) with 91 diverse bioactivities. It encompasses the physico-chemical properties of natural products, ADMET information, quantitative activity data with their potency, natural products contents with diverse fermentation conditions, systematic taxonomy, and links to various well-established databases. EMNPD aims to function as an open-access knowledge repository for the study of endophytic microorganisms and their natural products, thereby facilitating drug discovery research and exploration of bioactive substances. The database can be accessed at http://emnpd.idrblab.cn/ without the need for registration, enabling researchers to freely download the data. EMNPD is expected to become a valuable resource in the field of endophytic microorganism natural products and contribute to future drug development endeavors.

中文翻译：

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EMNPD：全面的内生微生物天然产物数据库，促进新生物活性物质的发现

内生微生物天然产物的发现和利用在药物研究中引起了极大的关注。尽管该领域每年都取得了显着进展，但显然缺乏专门用于内生微生物天然产物研究的开放获取数据库。为了满足与内生微生物天然产物相关的数据资源挖掘和共享日益增长的需求，本研究引入了 EMNPD，这是一个包含手动整理数据的综合内生微生物天然产物数据库。目前，EMNPD 提供来自 1017 种内生微生物的 6632 种天然产物，针对 1286 个实体（包括 94 个蛋白质、282 个细胞系和 910 个物种），具有 91 种不同的生物活性。它涵盖天然产物的理化性质、ADMET 信息、定量活性数据及其效力、不同发酵条件下的天然产物含量、系统分类以及各种成熟数据库的链接。EMNPD旨在作为内生微生物及其天然产物研究的开放获取知识库，从而促进药物发现研究和生物活性物质的探索。该数据库无需注册即可访问http://emnpd.idrblab.cn/，研究人员可以免费下载数据。EMNPD有望成为内生微生物天然产物领域的宝贵资源，并为未来的药物开发做出贡献。