Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body. Objectives: In this study, we aimed to investigate the relationship between Early Growth Response (EGR1, EGR2, and EGR3) protein levels in patients with Fibromyalgia Syndrome (FMS) and healthy controls. Methods: In our studies, 76 FMS patient group and 78 healthy control group who were newly diagnosed with primary FMS according to the 2010 American College of Rheumatology criteria for fibromyalgia in Sivas Cumhuriyet University Hospital, Physical Therapy, and Rehabilitation were used. Venous blood samples were taken from both groups for the measurement of EGR1, EGR2, and EGR3 protein plasma levels, and protein levels were determined using ELISA methods. Statistical parametric test assumptions were compared using the Independent Student's t-test. In addition, specificity, sensitivity, and AUC values were calculated with the ROC curve. Results: The relationship between plasma EGR1 protein levels of FMS patients and control groups was statistically significant (p=0.001). Conclusion: EGR1 protein levels were found to be lower in the patient group diagnosed with FMS compared to the control group. It has been suggested that EGR1 protein levels can be important in the diagnosis of FMS disease.

中文翻译：

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纤维肌痛综合征患者早期生长反应蛋白 [EGR] 水平的调查：一项横断面研究


背景：纤维肌痛是一种软组织风湿病，其特征是身体特定部位出现慢性、广泛的肌肉骨骼疼痛。目的：在本研究中，我们旨在探讨纤维肌痛综合征 (FMS) 患者和健康对照患者早期生长反应（EGR1、EGR2 和 EGR3）蛋白水平之间的关系。方法：在我们的研究中，纳入了在 Sivas Cumhuriyet 大学医院、物理治疗和康复中心根据 2010 年美国风湿病学会纤维肌痛标准新诊断为原发性 FMS 的 76 名 FMS 患者组和 78 名健康对照组。采集两组静脉血样本，测定血浆EGR1、EGR2、EGR3蛋白水平，并采用ELISA方法测定蛋白水平。使用独立学生 t 检验比较统计参数检验假设。此外，用ROC曲线计算特异性、敏感性和AUC值。结果：FMS患者血浆EGR1蛋白水平与对照组的相关性具有统计学意义（p=0.001）。结论：与对照组相比，诊断为 FMS 的患者组中 EGR1 蛋白水平较低。有人认为 EGR1 蛋白水平对于 FMS 疾病的诊断很重要。