Numerous bacterial species employ diffusible signal factor (DSF)-based quorum sensing (QS) as a widely conserved cell-cell signalling communication system to collectively regulate various behaviours crucial for responding to environmental changes. cis-11-Methyl-dodecenoic acid, known as DSF, was first identified as a signalling molecule in Xanthomonas campestris pv. campestris. Subsequently, many structurally related molecules have been identified in different bacterial species. This review aims to provide an overview of current understanding regarding the biosynthesis and regulatory role of DSF signals in both pathogenic bacteria and a biocontrol bacterium. Recent studies have revealed that the DSF-based QS system regulates antimicrobial factor production in a cyclic-di-GMP-independent manner in the biocontrol bacterium Lysobacter enzymogenes. Additionally, the DSF-family signals have been found to be involved in suppressing plant innate immunity. The discovery of these diverse signalling mechanisms holds significant promise for developing novel strategies to combat stubborn plant pathogens.

中文翻译：

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植物相关细菌中不同 DSF 家族群体感应信号的调节作用。

许多细菌物种采用基于扩散信号因子（DSF）的群体感应（QS）作为广泛保守的细胞间信号通信系统，共同调节对响应环境变化至关重要的各种行为。cis-11-甲基-十二碳烯酸，称为 DSF，首先被鉴定为野油菜黄单胞菌 pv. 中的信号分子。油菜。随后，在不同细菌物种中鉴定出许多结构相关的分子。本综述旨在概述目前对 DSF 信号在病原菌和生物防治细菌中的生物合成和调节作用的认识。最近的研究表明，基于 DSF 的 QS 系统以不依赖环二 GMP 的方式调节生物防治细菌溶酶杆菌中抗菌因子的产生。此外，还发现 DSF 家族信号参与抑制植物先天免疫。这些不同信号机制的发现为开发对抗顽固植物病原体的新策略带来了重大希望。