Depression is a mental disorder that is associated with low quality of life, increased risk of suicide and a high economic cost for society. Meta-analyses indicate that Meaning Centred Psychotherapies (MCP) are an efficacious psychotherapy to reduce depression in participants with chronic illness and cancer. However, to date, no systematic review has analysed the effectiveness of MCP in depressed participants who do not have a physical illness or cancer. The objective of this study was to carry out a systematic review to analyse the effectiveness of MCP in participants with depression and no physical illness. The search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Six studies (two randomised controlled trials and four quasi-experimental studies) were included in the systematic review. The results indicate that MCP is more effective than a control group as waitlist (four studies), psychoeducation group (one study), and cognitive behavioural therapy (CBT, one study), in reducing depressive symptoms, improving meaning in life and reducing anxiety in participants without physical illness. MCP would be considered a probably efficacious treatment for depression. However, further research with better experimental designs will be necessary to confirm the effectiveness of MCP for depression.

中文翻译：

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对抑郁参与者以意义为中心的心理治疗有效性的系统评价

抑郁症是一种精神障碍，与生活质量低下、自杀风险增加以及社会经济成本高有关。荟萃分析表明，以意义为中心的心理治疗（MCP）是一种有效的心理治疗，可以减少慢性病和癌症患者的抑郁症。然而，迄今为止，还没有系统评价分析 MCP 对没有身体疾病或癌症的抑郁参与者的有效性。本研究的目的是进行系统评价，分析 MCP 对患有抑郁症且无身体疾病的参与者的有效性。检索是按照系统评价和荟萃分析指南的首选报告项目（PRISMA）进行的。系统评价纳入了六项研究（两项随机对照试验和四项准实验研究）。结果表明，在减少抑郁症状、改善生活意义和减少焦虑方面，MCP 比候补组（四项研究）、心理教育组（一项研究）和认知行为疗法（CBT，一项研究）等对照组更有效。没有身体疾病的参与者。MCP 被认为是治疗抑郁症的一种可能有效的方法。然而，需要通过更好的实验设计进行进一步的研究，以证实 MCP 对抑郁症的有效性。