About 40% of nonsmall cell lung cancers (NSCLCs) have already progressed in an advanced stage at the time of diagnosis. Development of effective prevention and therapy approaches against NSCLC is critical for reducing mortality. As a fundamental ingredient of peppermint oil, menthol has been demonstrated to possess an antitumor activity in several types of carcinomas. However, the potential role of menthol on NSCLC has not been reported. The present study aims to investigate the effect and underlying mechanism of menthol on proliferation, apoptosis, and mobility of human lung adenocarcinoma.

中文翻译：

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薄荷醇通过Akt通路诱导细胞凋亡并抑制体内外非小细胞肺癌的增殖和迁移

大约 40% 的非小细胞肺癌 (NSCLC) 在诊断时已处于晚期。开发有效的非小细胞肺癌预防和治疗方法对于降低死亡率至关重要。作为薄荷油的基本成分，薄荷醇已被证明对多种类型的癌症具有抗肿瘤活性。然而，薄荷醇对非小细胞肺癌的潜在作用尚未见报道。本研究旨在探讨薄荷醇对人肺腺癌增殖、凋亡和迁移的影响及其潜在机制。