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Inflammatory Myofibroblastic Tumor in the Adrenal Gland: A Case Report.
Case Reports in Oncology Pub Date : 2023-10-16 , DOI: 10.1159/000534129
Reiko M Rodriguez-Nakamura 1 , Martin Sanchez-Garcia 1 , Arturo Del-Valle Rivera 1 , Elizabeth Mota-Garduño 1 , Leonora Chávez Mercado 2 , Sergio Adolfo Espinoza Guibarra 1 , Omar Vasquez-Gomez 3
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Inflammatory myofibroblastic tumors (IMTs) were first described by Harold Brunn in 1939. IMTs are mainly found in the lungs and other sites of the body; hence, its occurrence in the adrenal gland is exceptional. In the literature, less than 10 cases of IMTs in the adrenal gland have been reported. The etiology of IMT remains unknown, with post-inflammatory changes and a neoplastic origin being proposed. We present a case of a 19-year-old woman and adrenal gland IMT. The patient presented with abdominal pain and low cardiac output without hypovolemic shock. Computed tomography revealed a tumor in the adrenal gland measuring 11.4 cm with extravasation of contrast medium within the tumor. Treatment included conservative management with selective embolization due to minimal invasion of the inferior artery of the adrenal gland. The patient was then discharged with possibility of future elective surgery. Four months later, the size of the tumor decreased to 6.3 cm, and her Eastern Cooperative Oncology Group physical status was 0. The Multidisciplinary Tumor Board suggested surgical management. The final histopathology report was compatible with an IMT of the adrenal gland, with the immunohistochemical report showing positivity for anti-actin muscle-specific and anti-actin smooth muscle and negativity for anaplastic lymphoma kinase. IMTs of the adrenal gland may be treated electively through multidisciplinary management together with interventional radiology and surgery, achieving a favorable outcome for the patient.

中文翻译:

肾上腺炎性肌纤维母细胞肿瘤:病例报告。

炎症性肌纤维母细胞肿瘤(IMT)由 Harold Brunn 于 1939 年首次描述。IMT 主要发现于肺部和身体其他部位;因此,它在肾上腺中的发生是特殊的。文献中报道的肾上腺 IMT 病例不到 10 例。IMT 的病因仍不清楚,有人提出炎症后变化和肿瘤起源。我们介绍一名 19 岁女性肾上腺 IMT 病例。患者出现腹痛和低心输出量,无低血容量性休克。计算机断层扫描显示肾上腺内有一个 11.4 厘米的肿瘤,肿瘤内造影剂外渗。治疗包括保守治疗和选择性栓塞,因为肾上腺下动脉的侵犯最小。患者随后出院,并有可能在未来进行择期手术。四个月后,肿瘤大小缩小至6.3厘米,东部肿瘤合作组身体状况为0。多学科肿瘤委员会建议手术治疗。最终的组织病理学报告与肾上腺的 IMT 一致,免疫组织化学报告显示抗肌动蛋白肌肉特异性和抗肌动蛋白平滑肌呈阳性,而间变性淋巴瘤激酶呈阴性。肾上腺 IMT 可以通过多学科治疗结合介入放射学和手术进行选择性治疗,为患者取得良好的治疗效果。
更新日期:2023-10-16
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