Adolescent and young adult (AYA) cancer patients and survivors are a growing population due to more frequent diagnoses and improved survival. Fatigue is a common symptom experienced by cancer patients and it is often missed by health care professionals. Patient reported outcome measures (PROMs) can assist in evaluating patient reported fatigue. This systematic review aims to determine if AYA cancer patients report more fatigue than AYAs who have not been diagnosed with cancer. We used a subset of articles from a larger review that searched PubMed, EMBASE, CINAHL, and PsycINFO to determine which PROMs and domains are currently being used to evaluate AYA cancer. This study identified 175 articles related to PROMs in the AYA cancer population. Articles with PROMs reporting on fatigue/vitality were used in this review. From the original 175 articles, we identified 8 fatigue/vitality articles for this review. All eight articles found an increase in fatigue/decrease in vitality in the AYA cancer population compared to healthy controls. A meta-analysis was performed on four articles that used the same PROM tool (EORTC QLQ-C30). This found a statistically significant and clinically meaningful increase in mean fatigue of 12.5 95% confidence interval: 3.3-21.8 points (scale 0-100, higher number indicates more fatigue) in the AYA cancer group compared to healthy noncancer controls. Fatigue in the AYA cancer population is a significant issue, it is often undetected and underreported, and early interventions are needed to prevent the negative subsequent sequelae.

中文翻译：

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与非癌症患者相比，青少年和年轻成人癌症患者报告的疲劳：系统回顾和荟萃分析。

由于更频繁的诊断和生存率的提高，青少年 (AYA) 癌症患者和幸存者的数量不断增长。疲劳是癌症患者的常见症状，但经常被医疗保健专业人员忽视。患者报告的结果测量 (PROM) 可以帮助评估患者报告的疲劳。本系统评价旨在确定 AYA 癌症患者是否比未诊断出患有癌症的 AYA 报告更多的疲劳。我们使用了搜索 PubMed、EMBASE、CINAHL 和 PsycINFO 的大型综述中的文章子集，以确定当前使用哪些 PROM 和域来评估 AYA 癌症。这项研究确定了 175 篇与 AYA 癌症人群中 PROM 相关的文章。本次审查中使用了报告疲劳/活力的 PROM 文章。从最初的 175 篇文章中，我们为本次综述确定了 8 篇关于疲劳/活力的文章。所有八篇文章都发现，与健康对照组相比，AYA 癌症人群的疲劳程度增加/活力下降。对使用相同 PROM 工具 (EORTC QLQ-C30) 的四篇文章进行了荟萃分析。结果发现，与健康的非癌症对照组相比，AYA 癌症组的平均疲劳度增加了 12.5 个 95% 置信区间：3.3-21.8 分（范围 0-100，数字越高表示疲劳程度越高），具有统计显着性和临床意义。AYA 癌症人群的疲劳是一个重大问题，它常常未被发现且报告不足，需要早期干预以防止随后出现负面后遗症。