The 'One Health' (OH) approach is the most promising idea in realising the global goal of eliminating canine-mediated human rabies by 2030. However, taking an OH approach to rabies elimination can mean many different things to different people. We conducted a systematic review scrutinizing economic evaluations (EEs) retrieved from MEDLINE OVID, Embase OVID, Global Health OVID, CINAHL EBSCO and ECONLIT EBSCO that used the OH approach with the intent of identifying cost-effective sets of interventions that can be combined to implement an optimal OH-based rabies elimination program and highlight key gaps in the knowledge base. Our review suggests that an optimal OH program to tackle rabies should incorporate mass dog vaccination and integrated bite case management in combination with efficient use of post-exposure prophylaxis along with a shift to a 1-week abbreviated intradermal rabies vaccine regimen in humans. We recommend that future EEs of OH interventions for rabies elimination should be performed alongside implementation research to ensure proposed interventions are feasible and adopt a wider societal perspective taking into account costs and outcomes across both the human health and animal welfare sectors. The systematic review has been registered with PROSPERO.

中文翻译：

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One Health 消除狂犬病干预措施的成本效益：系统评价。

“同一个健康”(OH) 方法是实现到 2030 年消除犬介导的人类狂犬病这一全球目标的最有前途的想法。然而，采用 OH 方法来消除狂犬病对不同的人来说可能意味着许多不同的事情。我们对从 MEDLINE OVID、Embase OVID、Global Health OVID、CINAHL EBSCO 和 ECONLIT EBSCO 检索的经济评估 (EE) 进行了系统回顾，这些评估使用 OH 方法，旨在确定可组合实施的具有成本效益的干预措施。基于 OH 的最佳狂犬病消除计划，并强调知识库中的关键差距。我们的审查表明，应对狂犬病的最佳 OH 计划应将大规模狗疫苗接种和综合咬伤病例管理与有效使用暴露后预防相结合，并转向人类 1 周的简短皮内狂犬病疫苗方案。我们建议，未来消除狂犬病的 OH 干预措施应与实施研究同时进行，以确保拟议的干预措施可行，并采用更广泛的社会视角，同时考虑到人类健康和动物福利部门的成本和结果。系统评价已在 PROSPERO 注册。