Choline acetyltransferase (ChAT) is required for the biosynthesis of acetylcholine, the molecular mediator that inhibits cytokine production in the cholinergic anti-inflammatory pathway of the vagus nerve inflammatory reflex. Abundant work has established the biology of cytoplasmic ChAT in neurons, but much less is known about the potential presence and function of ChAT in the extracellular milieu.

中文翻译：

---

循环细胞外胆碱乙酰转移酶调节炎症

乙酰胆碱的生物合成需要胆碱乙酰转移酶 (ChAT)，乙酰胆碱是抑制迷走神经炎症反射的胆碱能抗炎途径中细胞因子产生的分子介质。大量的工作已经建立了神经元细胞质 ChAT 的生物学特性，但对 ChAT 在细胞外环境中的潜在存在和功能知之甚少。