Assessing bone’s response to physical activity interventions is challenging. This randomized controlled trial investigates if changes in bone turnover markers can offer an early evaluation of a physical activity intervention’s effectiveness in improving bone mineral density (BMD) in premenopausal women. Participants in the intervention group (n = 27, with 24 completing the trial) were instructed to walk at least 10,000 steps every day on a brisk walk and to execute 60 jumps daily, each surpassing 4g of acceleration, using an accelerometer-based wearable device. Meanwhile, the control group (n = 26, with 18 completing the trial) continued with their usual lifestyle. Bone turnover markers, comprising of C-terminal telopeptide of Type I collagen, procollagen Type 1 N-terminal propeptide, and total osteocalcin (carboxylated and undercarboxylated) were measured at baseline and midway through the intervention (3 months). Dual-energy X-ray absorptiometry scans of the hip and lumbar spine were conducted at baseline and the end of the intervention (6 months) to estimate BMD. Analysis of covariance exhibited significant differences between groups in procollagen Type 1 N-terminal propeptide (−6.74 μg/L, p = .023) and C-terminal telopeptide of Type I collagen (−83 ng/L, p = .043) after 3 months, and in femoral neck BMD (+0.024 g/cm², p = .016), total hip BMD (+0.036 g/cm², p = .004), and lumbar spine BMD (+0.026 g/cm², p = .020) after 6 months. A significant correlation (r = −.73; p < .001) was detected between reductions in C-terminal telopeptide of Type I collagen and increases in femoral neck BMD. In conclusion, this intervention improved BMD in premenopausal women, with bone turnover markers potentially useful for early intervention assessment, though further research is needed.

评估骨骼对身体活动干预的反应具有挑战性。这项随机对照试验调查骨转换标志物的变化是否可以早期评估体力活动干预在改善绝经前女性骨矿物质密度 (BMD) 方面的有效性。干预组的参与者（n  = 27，其中 24 人完成试验）被要求每天快走至少 10,000 步，并每天进行 60 次跳跃，每次跳跃的加速度超过 4 g，使用基于加速度计的可穿戴设备设备。与此同时，对照组（n  = 26，其中 18 人完成试验）继续他们通常的生活方式。在基线和干预中期（3 个月）测量骨转换标志物，包括 I 型胶原 C 端端肽、1 型原胶原 N 端前肽和总骨钙素（羧化和羧化不足）。在基线和干预结束（6 个月）时对髋部和腰椎进行双能 X 射线骨密度扫描，以估计 BMD。协方差分析显示，1 型原胶原 N 端前肽（−6.74 μg/L，p  = .023）和 I 型胶原 C 端端肽（−83 ng/L，p  = .043）在各组之间存在显着差异。 3 个月，股骨颈 BMD (+0.024 g/cm ² , p  = .016)、全髋部 BMD (+0.036 g/cm ² , p  = .004) 和腰椎 BMD (+0.026 g/cm ²，p  = .020) 6 个月后。 I 型胶原 C 末端端肽的减少与股骨颈 BMD 的增加之间存在显着相关性（r  = -.73；p < .001）。总之，这种干预措施改善了绝经前女性的骨密度，骨转换标志物可能对早期干预评估有用，但还需要进一步研究。