Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we have minimal control over its reoccurrence and resistance to current pharmacotherapies. The endocannabinoid system (ECS) has recently been accepted as a multifaceted homeostatic regulator, influencing various physiological processes across different biological compartments, including the skin. This review presents an overview of the pathophysiology of melanoma, current pharmacotherapy used for treatment, and the challenges associated with the different pharmacological approaches. Furthermore, it highlights the utility of cannabinoids as an additive remedy for melanoma by restoring the balance between downregulated immunomodulatory pathways and elevated inflammatory cytokines during chronic skin conditions as one of the suggested critical approaches in treating this immunogenic tumor.

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合理化大麻素与当前黑色素瘤治疗药物疗法的前瞻性耦合效应

黑色素瘤是主要致命的癌症之一，但从治疗的角度来看，我们对其复发和对当前药物疗法的耐药性的控制微乎其微。内源性大麻素系统（ECS）最近被认为是一种多方面的稳态调节剂，影响包括皮肤在内的不同生物区室的各种生理过程。本综述概述了黑色素瘤的病理生理学、当前用于治疗的药物疗法以及与不同药理学方法相关的挑战。此外，它还强调了大麻素作为黑色素瘤补充疗法的效用，通过恢复慢性皮肤病期间下调的免疫调节途径和升高的炎症细胞因子之间的平衡，作为治疗这种免疫原性肿瘤的建议关键方法之一。