CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells,Cancer Biology & Therapy

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CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
Cancer Biology & Therapy ( IF 3.6 ) Pub Date : 2023-11-30 , DOI: 10.1080/15384047.2023.2279241
Zibo Chen ₁ , Xi Liu ₁ , Masanori Kawakami ₁ , Xiuxia Liu ₁ , Allison Baker ₂ , Aayush Bhatawadekar ₂ , Liliya Tyutyunyk-Massey ₁ , Kedar Narayan ₂ , Ethan Dmitrovsky ₁

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Cyclin-dependent Kinase 2 (CDK2) inhibition prevents supernumerary centrosome clustering. This causes multipolarity, anaphase catastrophe and apoptotic death of aneuploid cancers. This study elucid...

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