The interactions between a gemini surfactant 12-2-12 and bovine serum albumin (BSA) have been studied in aqueous and mixed aqueous media by conductance measurements using the iterative method at different temperatures ranging from 298.15 K to 313.15 K with step size 5. The critical micellar concentration (CMC) as well as the degree of ionization for the micelles (α) have been evaluated and their variation with solvent type and temperature has been discussed. The error for conductivity measurements was calculated and found to be much smaller than for surface tension measurements using the platinum ring method. The CMC values for the mixture of 12-2-12 and BSA in aqueous solvent solutions follow the sequence: DMF > AN > DMSO > water. These values were further confirmed by surface tension studies. From the thermodynamic parameters, hydrophobic interactions were found to be the driving force for micellization. The existence of enthalpy-entropy compensation was established from the linear plot of ΔH° m and ΔS° m .

中文翻译：

---

在有机溶剂和温度存在下，迭代评估 12-2-12 在 1% BSA 水溶液中的胶束和热力学性质

Gemini 表面活性剂 12-2-12 与牛血清白蛋白 (BSA) 之间的相互作用已在水性和混合水性介质中通过电导测量进行了研究，使用迭代方法在 298.15 K 至 313.15 K 的不同温度范围内，步长为 5。临界胶束浓度 (CMC) 以及胶束的电离程度（α）已被评估，并讨论了它们随溶剂类型和温度的变化。计算发现电导率测量的误差比使用铂环法测量表面张力的误差小得多。12-2-12 和 BSA 在水性溶剂溶液中的混合物的 CMC 值遵循以下顺序：DMF > AN > DMSO > 水。这些值通过表面张力研究得到进一步证实。从热力学参数来看，发现疏水相互作用是胶束化的驱动力。从 Δ 的线性图证实了熵-熵补偿的存在H° 米 和 ΔS° 米 。