Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1–14. Their structures were determined by spectroscopic analysis as three previously undescribed C13-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4–14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC50 value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC50 value of 0.8 ± 0.3 µM. Three previously unreported compounds 1–3 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively.

中文翻译：

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药草来源真菌球毛壳菌 Km1226 的化学成分

内生真菌已被证明是新型天然产物的丰富来源，具有广泛的生物活性和较高水平的结构多样性。对从沿海药草 Atriplex maximowicziana Makino 中分离出的球形毛壳 Km1226 的液态和固态发酵产物进行化学研究，分离出化合物 1-14。通过光谱分析确定其结构为三种先前未描述的 C13-聚酮化合物，即 aureonitol C (1)、mollipilins G (2) 和 H (3)，以及 11 种已知化合物 4-14。其中，mollipilin A (5) 在 LPS 诱导的 BV-2 小胶质细胞中表现出显着的一氧化氮生成抑制活性，IC50 值为 0.7 ± 0.1 µM，毛球蛋白 D (10) 在人内皮祖细胞中表现出有效的抗血管生成特性细胞 (EPC) 的 IC50 值为 0.8 ± 0.3 µM。分离并鉴定了三种以前未报道的化合物 1-3。Mollipilin A (5) 和 chaetoglobosin D (10) 可能分别开发为抗炎和抗血管生成先导药物。