The prevalence of antibiotic-resistant urogenital mycoplasmas and ureaplasmas has been gradually increasing over the years, leading to greater concern for accurate diagnosis and treatment. In this study, the antimicrobial resistance trends in Greece were analyzed using 2992 Ureaplasma spp. and 371 M. hominis isolates collected between 2014 and 2022. Antibiotic sensitivity was determined using eight different antimicrobial agents (josamycin, pristinamycin, clindamycin, ofloxacin, azithromycin, tetracycline, erythromycin, and doxycycline), with the data analyzed using descriptive statistical methods. Resistance rates to clindamycin and erythromycin increased for both M. hominis and Ureaplasma spp., while remaining relatively low for Tetracycline, Doxycycline, and Ofloxacin. For Ureaplasma spp., high susceptibility was observed to pristinamycin, tetracycline, doxycycline, azithromycin, and josamycin, and intermediate susceptibility to erythromycin. However, the resistance rate for clindamycin dramatically increased from 60% in 2014 to a peak of 98.46% in 2021, and the erythromycin resistance rate increased from 9.54% in 2018 to 22.13% in 2021. M. hominis exhibited consistently high resistance rates to Erythromycin, while Azithromycin resistance significantly increased over time, from 52.78% in 2017 to 97.22% in 2022. The alarming escalation in antibiotic-resistant urogenital mycoplasmas and ureaplasmas in the Greek population is a significant concern. Antibiotic overconsumption may have played a crucial role in increasing resistance trends. The implementation of nationwide surveillance systems, proper antibiotic stewardship policies, and appropriate culture-based therapy policies are necessary to effectively control this emerging risk.

近年来，耐抗生素泌尿生殖支原体和解脲支原体的患病率逐渐增加，导致人们更加关注准确诊断和治疗。在这项研究中，使用 2992 种解脲支原体对希腊的抗菌药物耐药性趋势进行了分析。2014 年至 2022 年间收集了 371 株人型分枝杆菌分离株。使用八种不同的抗菌药物（交沙霉素、普那霉素、克林霉素、氧氟沙星、阿奇霉素、四环素、红霉素和强力霉素）测定抗生素敏感性，并使用描述性统计方法对数据进行分析。人支原体和解脲支原体对克林霉素和红霉素的耐药率均有所增加，而四环素、强力霉素和氧氟沙星的耐药率相对较低。对于解脲支原体，观察到对原始霉素、四环素、多西环素、阿奇霉素和交沙霉素高度敏感，对红霉素中等敏感。然而，克林霉素耐药率从2014年的60%急剧上升到2021年的峰值98.46%，红霉素耐药率从2018年的9.54%上升到2021年的22.13%。人型支原体对红霉素的耐药率持续较高。 ，而阿奇霉素耐药性随着时间的推移显着增加，从 2017 年的 52.78% 增加到 2022 年的 97.22%。希腊人群中抗生素耐药性泌尿生殖支原体和解脲支原体的惊人增加令人担忧。抗生素的过度消费可能在耐药性趋势增加中发挥了至关重要的作用。为了有效控制这一新出现的风险，有必要实施全国性的监测系统、适当的抗生素管理政策和适当的基于培养的治疗政策。