Doxorubicin-induced cardiomyopathy (DICM) is associated with a poor prognosis, and effective therapeutic drug candidates have yet to be identified. Furthermore, whether basic animal models reflect the clinical pathogenesis of DICM should be carefully examined. Although the exact mechanisms underlying the development of DICM are complex and remain unclear, oxidative stress is strongly implicated as a contributing factor. Therefore, we investigated the effects of ginseng (the root of Panax ginseng: Gin), an inexpensive and safe drug with antioxidant properties. We previously conducted a meta-analysis that yielded results suggesting its efficacy in humans. However, this study did not examine the efficacy of ginseng in detail. Therefore, this study investigated the efficacy of red ginseng (steamed and dried ginseng cultivated for over six years; RGin) in a mouse model of chronic DICM to elucidate its potential therapeutic benefits. RGin prevented the decrease in left ventricular ejection fraction associated with doxorubicin (DXR) administration and prolonged survival in DBA/2 mice. In addition, RGin reduced DXR-induced cardiomyocyte damage. These findings highlight its potential as a therapeutic option for the treatment of DICM.

中文翻译：

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红参是治疗小鼠慢性阿霉素诱发心肌病的候选药物

阿霉素诱发的心肌病（DICM）与不良预后相关，有效的候选治疗药物尚未确定。此外，基础动物模型是否反映DICM的临床发病机制值得仔细研究。尽管 DICM 发生的确切机制很复杂且仍不清楚，但氧化应激是一个重要的影响因素。因此，我们研究了人参（ Panax ginseng的根：Gin）的作用，这是一种廉价且安全的具有抗氧化特性的药物。我们之前进行了一项荟萃分析，结果表明其对人类的功效。然而，这项研究并没有详细考察人参的功效。因此，本研究研究了红参（栽培六年以上的蒸干人参；RGin）在慢性 DICM 小鼠模型中的功效，以阐明其潜在的治疗益处。RGin 可防止与阿霉素 (DXR) 给药相关的左心室射血分数下降，并延长 DBA/2 小鼠的生存期。此外，RGin 还可减少 DXR 诱导的心肌细胞损伤。这些发现凸显了其作为 DICM 治疗选择的潜力。