Association between advanced glycation end products and sarcopenia: The mediating role of osteoporosis.,The Journal of Clinical Endocrinology & Metabolism

当前位置： X-MOL 学术 › J. Clin. Endocrinol. Metab. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Association between advanced glycation end products and sarcopenia: The mediating role of osteoporosis.
The Journal of Clinical Endocrinology & Metabolism ( IF 5.8 ) Pub Date : 2023-10-31 , DOI: 10.1210/clinem/dgad640
Xingyu Zhang _{1,

2} , Xiaoyu Chen ₁ , Shengjie Li _{1,

2} , Mengze Gao _{1,

2} , Peipei Han ₁ , Liou Cao ₃ , Jing Gao ₄ , Qiongying Tao ₅ , Jiayi Zhai ₅ , Dongyu Liang ₆ , Li Qin ₇ , Qi Guo ₁

Affiliation

BACKGROUND Advanced glycation end products (AGEs) are a group of molecules formed through non-enzymatic reactions. These compounds were associated to several age-related diseases, including sarcopenia and osteoporosis. OBJECTIVE To investigate the relationships between AGEs, osteoporosis, and sarcopenia in community-dwelling older adults. MATERIALS AND METHODS This cross-sectional study included 1991 older adults aged 72.37 ± 5.90 years from China. AGE levels were measured by AGE ReaderTM device. Bone mineral density was assessed using dual-energy X-ray absorptiometry, and osteoporosis was diagnosed based on a T score < -2.5. Sarcopenia was defined as loss of muscle mass plus loss of muscle strength and/or reduced physical performance. Presarcopenia was defined as low muscle mass with normal muscle strength and normal physical performance. RESULTS The prevalence of sarcopenia was 18.5%, and that of osteoporosis was 40.5%. Compared to the lowest AGE quartile, the highest AGE quartile showed a significant association with sarcopenia (OR 2.42, 95% CI [1.60, 3.66]) (P for trend <0.001), but not with presarcopenia. Per standard deviation(SD) increase in AGE was associated with higher odds of sarcopenia(OR 1.44, 95% CI [1.26, 1.66]). Additionally, in the mediation analysis, when AGEs were treated as a continuous variable (the mediation effect is denoted by Za*Zb = 18.81, 95% CI [8.07, 32.32]-the 95% CI does not contain zero, representing a significant mediating effect) or a categorical variable (the mediating effect is expressed as Zmediation = 3.01 > 1.96, which represents a significant mediating effect), osteoporosis played a partial mediating role in the association between AGEs and sarcopenia. CONCLUSIONS Elevated AGEs are associated with sarcopenia but not with presarcopenia. This association was partially mediated by osteoporosis.

更新日期：2023-10-31

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文

全部期刊列表>>