BACKGROUND Intervertebral disc degeneration is a major cause of low back pain, and several studies have evaluated the efficacy of extracellular vesicles in the treatment of intervertebral disc degeneration. METHODS The databases Pubmed, Embase, and Cochrane Library were systematically searched from inception to the end of 2022 to identify studies investigating the therapeutic potential of cell-derived extracellular vesicles for intervertebral disc degeneration (IDD) treatment.The following outcome measures were utilized: MRI Pfirrmann grading system, Disc Height Index (DHI), histological grading, and apoptosis rate. RESULTS A comprehensive meta-analysis was conducted, including a total of 13 articles comprising 19 studies involving 218 experimental animals.Comparative analysis between normal cell-derived extracellular vesicles and placebo revealed significant reductions in MRI grade, increased DHI values, decreased nucleus pulposus cell apoptosis rates, and improved tissue grades. CONCLUSIONS These findings collectively demonstrate the effective inhibition of intervertebral disc degeneration through the application of extracellular vesicles derived from cells.In conclusion, this study provides an updated synthesis of evidence supporting the efficacy of extracellular vesicles as a promising therapeutic approach for IVDD treatment.

中文翻译：

---

细胞外囊泡在治疗椎间盘退变中的潜在用途。

背景技术椎间盘退变是腰痛的主要原因，多项研究评估了细胞外囊泡在治疗椎间盘退变中的功效。方法 从成立到 2022 年底，系统地检索了 Pubmed、Embase 和 Cochrane Library 数据库，以识别研究细胞源性细胞外囊泡治疗椎间盘退变 (IDD) 的潜力的研究。采用了以下结果测量： MRI Pfirrmann 分级系统、椎间盘高度指数 (DHI)、组织学分级和细胞凋亡率。结果 进行了全面的荟萃分析，包括总共 13 篇文章，包括 19 项研究，涉及 218 只实验动物。正常细胞源性细胞外囊泡与安慰剂之间的比较分析显示 MRI 等级显着降低，DHI 值增加，髓核细胞凋亡减少率，并提高组织等级。结论 这些研究结果共同证明了通过应用细胞来源的细胞外囊泡可以有效抑制椎间盘退变。总之，本研究提供了最新的证据综合，支持细胞外囊泡作为 IVDD 治疗的一种有前途的治疗方法的功效。