CONTEXT Chronic kidney disease (CKD) is a world-wide health problem. Recent literature has shown an association of hemoglobin glycation index (HGI) and CKD in patients with dysglycemia. OBJECTIVE The aim of this study was to reveal impact of HGI as a predictor for incident CKD in the general population. METHODS CKD was defined as dipstick proteinuria or estimated glomerular rate (eGFR) < 60 ml/min/1.73 m2. Impact of HGI on incident CKD was assessed using the data from CKD-free health examinees (N = 23,467, 4.1% of them diabetes) followed up for the mean of 5.1 years: Cox proportional hazards model was employed with multivariate adjustment for age, systolic blood pressure, eGFR, fasting plasma glucose, body mass index, log[alanine aminotransferase], log[triglycerides], high-density-lipoprotein-cholesterol, platelets counts, smoking and sex. Elevated level of HGI in subjects with CKD was ascertained after propensity score matching of another group of health examinees (N = 2580, 7.6% of them diabetes). RESULTS In the former group, CKD developed in 2,540 subjects and HGI was the second most robust predictor for it following low eGFR. With adjustment for the eleven covariates, HR of HGI (95%CI) for CKD was 1.293 (1.238 to 1.349) (P < 0.0001). Population attributable risk of HGI for CKD was 4.2%. In the latter group, among 708 subjects matched 1:1 for nine covariates, HGI was significantly elevated in subjects with CKD： -0.208 (-0.504 to -0.156) vs -0.284 to (-0.582 to 0.052). (median (IQR), P = 0.03). CONCLUSION HGI was a novel risk factor for CKD in the general population.

中文翻译：

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血红蛋白糖化指数，表面健康人群中慢性肾病发生的新危险因素。

背景 慢性肾脏病 (CKD) 是一个世界性的健康问题。最近的文献表明，血糖异常患者的血红蛋白糖化指数 (HGI) 与 CKD 存在关联。目的 本研究的目的是揭示 HGI 作为一般人群 CKD 事件预测因子的影响。方法 CKD 定义为试纸蛋白尿或估计肾小球率 (eGFR) < 60 ml/min/1.73 m2。HGI 对 CKD 事件的影响使用无 CKD 健康检查者（N = 23,467 名，其中 4.1% 患有糖尿病）的数据进行评估，随访时间为平均 5.1 年：采用 Cox 比例风险模型，对年龄、收缩压进行多变量调整血压、eGFR、空腹血糖、体重指数、log[丙氨酸氨基转移酶]、log[甘油三酯]、高密度脂蛋白胆固醇、血小板计数、吸烟和性别。在对另一组健康受试者（N = 2580，其中 7.6% 患有糖尿病）进行倾向评分匹配后，确定了 CKD 受试者的 HGI 水平升高。结果 在前一组中，2,540 名受试者出现了 CKD，HGI 是继低 eGFR 之后第二个最有力的预测因子。调整十一个协变量后，CKD 的 HGI (95% CI) HR 为 1.293（1.238 至 1.349）（P < 0.0001）。HGI 导致 CKD 的人群归因风险为 4.2%。在后一组中，在 9 个协变量 1:1 匹配的 708 名受试者中，患有 CKD 的受试者的 HGI 显着升高：-0.208（-0.504 至 -0.156） vs -0.284 至（-0.582 至 0.052）。（中位数（IQR），P = 0.03）。结论 HGI 是普通人群中 CKD 的一个新危险因素。