Regeneration after tissue injury is a dynamic and complex process, and angiogenesis is necessary for normal physiological activities and tissue repair. Induced pluripotent stem cells are a new approach in regenerative medicine, which provides good model for the study of difficult-to-obtain human tissues, patient-specific therapy, and tissue repair. As an innovative cell-free therapeutic strategy, the main advantages of the treatment of induced pluripotent stem cells (iPSCs)-derived exosomes are low in tumorigenicity and immunogenicity, which become an important pathway for tissue injury. This review focuses on the mechanism of the angiogenic effect of iPSCs-derived exosomes on wound repair in tissue injury and their potential therapeutic targets, with a view to providing a theoretical basis for the use of iPSCs-derived exosomes in clinical therapy.

中文翻译：

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组织损伤中血管生成的新策略：iPSC 衍生的外泌体的治疗效果。

组织损伤后的再生是一个动态而复杂的过程，血管生成是正常生理活动和组织修复所必需的。诱导多能干细胞是再生医学的一种新方法，为研究难以获得的人体组织、患者特异性治疗和组织修复提供了良好的模型。作为一种创新的无细胞治疗策略，诱导多能干细胞（iPSC）来源的外泌体治疗的主要优点是致瘤性和免疫原性低，成为组织损伤的重要途径。本综述重点阐述iPSCs源性外泌体对组织损伤创面修复的血管生成作用机制及其潜在的治疗靶点，以期为iPSCs源性外泌体在临床治疗中的应用提供理论依据。