Nonossifying fibroma (NOF) is a common benign bone neoplasm and is usually observed in the first 2 decades of life. Most NOFs occur in the metaphysis of long bones of the lower extremities and migrate toward the diaphysis during skeletal maturation. Epiphyseal involvement by NOF has been rarely reported, with only one case found in the English literature. The authors report the second case of NOF involving the epiphysis of a long bone, the proximal tibia of a 21-year-old woman. Clinicians and pathologists should be aware of the rare possibility of epiphyseal involvement of long bones by this condition. Pathologists should select appropriate immunohistochemistry markers to rule out alternative diagnoses.

中文翻译：

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累及长骨骨骺的非骨化性纤维瘤病例报告及文献复习。

非骨化性纤维瘤 (NOF) 是一种常见的良性骨肿瘤，通常在生命的前 20 年内观察到。大多数NOF发生在下肢长骨的干骺端，并在骨骼成熟过程中向骨干迁移。NOF 累及骨骺的报道很少，英文文献中仅发现一例。作者报告了第二例涉及长骨骨骺（即胫骨近端）的 NOF 病例，患者为一名 21 岁女性。临床医生和病理学家应该意识到这种情况极有可能累及长骨骨骺。病理学家应选择适当的免疫组织化学标记物以排除其他诊断。