Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and hippocampal sclerosis of aging (HS-A) pathologies are found together at autopsy in ∼20% of elderly demented persons. Although astrocytosis is known to occur in neurodegenerative diseases, it is currently unknown how the severity of astrocytosis is correlated with the common combinations of pathologies in aging brains. To address this knowledge gap, we analyzed a convenience sample of autopsied subjects from the University of Kentucky Alzheimer's Disease Research Center community-based autopsy cohort. The subjects were stratified into 5 groups (n = 51 total): pure ADNC, ADNC + LATE-NC, ADNC + HS-A, ADNC + LATE-NC + HS-A, and low-pathology controls. Following GFAP immunostaining and digital slide scanning with a ScanScope, we measured GFAP-immunoreactive astrocytosis. The severities of GFAP-immunoreactive astrocytosis in hippocampal subfield CA1 and subiculum were compared between groups. The group with ADNC + LATE-NC + HS-A had the most astrocytosis as operationalized by either any GFAP+ or strong GFAP+ immunoreactivity in both CA1 and subiculum. In comparison to that pathologic combination, ADNC + HS or ADNC + LATE-NC alone showed lower astrocytosis. Pure ADNC had only marginally increased astrocytosis in CA1 and subiculum, in comparison to low-pathology controls. We conclude that there appeared to be pathogenetic synergy such that ADNC + LATE-NC + HS-A cases had relatively high levels of astrocytosis in the hippocampal formation.

中文翻译：

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在严重的 ADNC 中，合并 LATE-NC 和海马硬化的海马比单独患有 LATE-NC 或海马硬化的海马有更多的星形细胞增多症。

大约 20% 的老年痴呆症患者在尸检中同时发现边缘系统主导的年龄相关 TDP-43 脑病神经病理改变 (LATE-NC) 和老年海马硬化 (HS-A) 病理。尽管已知星形细胞增多症发生在神经退行性疾病中，但目前尚不清楚星形细胞增多症的严重程度如何与衰老大脑中常见的病理组合相关。为了解决这一知识差距，我们分析了来自肯塔基大学阿尔茨海默病研究中心社区尸检队列的尸检受试者样本。将受试者分为 5 组（总共 51 名）：纯 ADNC、ADNC + LATE-NC、ADNC + HS-A、ADNC + LATE-NC + HS-A 和低病理对照。在使用 ScanScope 进行 GFAP 免疫染色和数字载玻片扫描后，我们测量了 GFAP 免疫反应性星形细胞增多症。比较组间海马 CA1 亚区和下托 GFAP 免疫反应性星形细胞增多症的严重程度。ADNC + LATE-NC + HS-A 组的星形细胞增多症最多，由 CA1 和下托中的任何 GFAP+ 或强 GFAP+ 免疫反应性进行操作。与病理组合相比，单独的 ADNC + HS 或 ADNC + LATE-NC 显示出较低的星形细胞增多症。与低病理对照相比，纯 ADNC 仅略微增加了 CA1 和下托的星形细胞增多。我们得出的结论是，ADNC + LATE-NC + HS-A 病例似乎存在致病协同作用，海马结构中星形细胞增多水平相对较高。