The Global Registry of Acute Coronary Events (GRACE) score and the systemic immune-inflammation index (SII) were used independently to predict adverse outcomes in patients with ST-elevation myocardial infarction (STEMI). In this study, 1041 patients with STEMI were divided into 4 groups based on GRACE scores and optimal cutoff values for SII. SII was positively correlated with GRACE score (r = 0.164; P < .001). SII (HR, hazard ratio: 2.051; 95%CI: 1.249-3.368; P = .005) and GRACE score (HR: 7.625; 95%CI: 3.692-15.746; P < .001) were independent risk predictors of short-term major adverse cardiovascular events (MACEs). Taking the low SII+low GRACE group as the reference group, the short-term MACE HR of the high SII+high GRACE group was 40.470 (95%CI: 5.547-295.253). Comparing the area under the curve, the combined use of SII and GRACE scores can significantly improve the prediction efficiency of short-term MACE compared with the single use of SII and GRACE scores. In conclusion, SII may be positively correlated with GRACE score, and the combination of the two accurately predicted the occurrence of short-term MACE in STEMI patients after percutaneous coronary intervention (PCI).

中文翻译：

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GRACE风险评分联合全身免疫炎症指数对经皮冠状动脉介入治疗后ST段抬高型心肌梗死患者的预后价值。

急性冠脉事件全球登记 (GRACE) 评分和全身免疫炎症指数 (SII) 独立用于预测 ST 段抬高型心肌梗死 (STEMI) 患者的不良后果。在这项研究中，1041 名 STEMI 患者根据 GRACE 评分和 SII 最佳截止值分为 4 组。SII 与 GRACE 评分呈正相关（r = 0.164；P < .001）。SII（HR，风险比：2.051；95%CI：1.249-3.368；P = .005）和 GRACE 评分（HR：7.625；95%CI：3.692-15.746；P < .001）是短期风险的独立风险预测因子。术语“主要不良心血管事件（MACE）”。以低SII+低GRACE组为参照组，高SII+高GRACE组的短期MACE HR为40.470（95%CI：5.547-295.253）。比较曲线下面积，联合使用SII和GRACE评分相比单独使用SII和GRACE评分可以显着提高短期MACE的预测效率。总之，SII可能与GRACE评分呈正相关，两者联合准确预测STEMI患者经皮冠状动脉介入治疗（PCI）后短期MACE的发生。