Introduction Lambert-Eaton myasthenia syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies targeting presynaptic neuromuscular junctions. It results in muscle weakness and autonomic dysfunction. LEMS can be idiopathic or associated with neoplastic diseases, often small-cell lung cancer. This case report describes a rare instance of paraneoplastic LEMS in a man with non-Hodgkin lymphoma. Case Presentation A 57-year-old male with non-Hodgkin lymphoma presented with progressive muscle weakness, diminished reflexes, and autonomic symptoms. Diagnosis revealed LEMS with autoantibodies against voltage-gated calcium channels. Immunosuppressive therapy and lymphoma treatment led to significant improvement in his condition. Conclusion This case highlights the rare occurrence of paraneoplastic LEMS in a patient with non-Hodgkin lymphoma. Recognition and timely management of LEMS alongside lymphoma treatment can lead to significant clinical improvement, emphasizing the need for increased awareness of such complex associations.

中文翻译：

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与非霍奇金淋巴瘤相关的兰伯特-伊顿肌无力综合征罕见病例：病例报告和文献综述。

简介 兰伯特-伊顿肌无力综合征 (LEMS) 是一种罕见的自身免疫性疾病，其特征是针对突触前神经肌肉接头的自身抗体。它会导致肌肉无力和自主神经功能障碍。LEMS 可以是特发性的，也可以与肿瘤性疾病（通常是小细胞肺癌）相关。本病例报告描述了一名患有非霍奇金淋巴瘤的男性出现副肿瘤性 LEMS 的罕见病例。病例介绍 一名 57 岁男性，患有非霍奇金淋巴瘤，表现为进行性肌肉无力、反射减弱和自主神经症状。诊断显示 LEMS 具有针对电压门控钙通道的自身抗体。免疫抑制治疗和淋巴瘤治疗使他的病情显着改善。结论 该病例凸显了非霍奇金淋巴瘤患者副肿瘤性 LEMS 的罕见发生。认识并及时管理 LEMS 与淋巴瘤治疗可以带来显着的临床改善，强调需要提高对这种复杂关联的认识。