Abstract

Geroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve functioning of various organ systems and enhance their homeostatic capabilities. We have developed a system of criteria for geroprotectors and proposed their classification based on the mechanisms of their action on the aging processes. Geroprotectors are required to reduce mortality, improve human aging biomarkers, have minimal side effects, and enhance quality of life. Additionally, there are approaches based on combining geroprotectors targeted to different targets and mechanisms of aging to achieve maximum effectiveness. Currently, numerous preclinical studies are being conducted to identify new molecular targets and develop new approaches to extend healthy aging, although the number of clinical trials is limited. Geroprotectors have the potential to become a new class of preventive medicines as they prevent onset of certain diseases or slow down their progression.

中文翻译：

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潜在的老年保护剂——从实验室到临床

摘要

老年保护剂是减缓衰老过程的物质，可用于预防与年龄相关的疾病。老年保护剂可以改善各种器官系统的功能并增强其体内平衡能力。我们开发了一套老年保护剂标准体系，并根据其对衰老过程的作用机制提出了分类。需要老年保护剂来降低死亡率、改善人类衰老生物标志物、最小化副作用并提高生活质量。此外，还有一些方法基于结合针对不同目标和衰老机制的老年保护剂，以实现最大效果。目前，尽管临床试验的数量有限，但正在进行大量临床前研究，以确定新的分子靶点并开发新的方法来延长健康衰老。老年保护剂有潜力成为一类新型预防药物，因为它们可以预防某些疾病的发作或减缓其进展。