Protein A affinity chromatography is a well-established method currently used in the pharmaceutical industry. However, the high costs usually associated with chromatographic separation of protein A and the difficulties in continuous operation make the investigation of alternative purification methods very important.

中文翻译：

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直接从收获的细胞培养液中纯化阿达木单抗的替代方法的开发和比较。

Protein A 亲和层析是目前制药行业中使用的一种成熟的方法。然而，蛋白 A 的色谱分离通常成本高昂，且连续操作困难，因此研究替代纯化方法非常重要。