Although hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anemia, their effects on cardiac and renal dysfunction remain unknown. We previously reported on Dahl salt-sensitive rats, in a rat model of salt-sensitive hypertension, that exhibited anemia and impaired expression of duodenal iron transporters after the development of hypertensive cardiac and renal dysfunction. Therefore, we investigated the effects of Roxadustat (FG-4592), an HIF-PH inhibitor, on anemia, iron regulation, and cardiac and renal dysfunction in Dahl salt-sensitive rats.

中文翻译：

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缺氧诱导因子脯氨酰羟化酶抑制剂 Roxadustat (FG-4592) 可减少 Dahl 盐敏感大鼠的肾纤维化。

尽管缺氧诱导因子脯氨酰羟化酶（HIF-PH）抑制剂已被开发用于治疗肾性贫血，但其对心脏和肾功能障碍的影响仍不清楚。我们之前报道了 Dahl 盐敏感大鼠，在盐敏感高血压大鼠模型中，在发生高血压心肾功能障碍后表现出贫血和十二指肠铁转运蛋白表达受损。因此，我们研究了 HIF-PH 抑制剂 Roxadustat (FG-4592) 对 Dahl 盐敏感大鼠的贫血、铁调节以及心肾功能障碍的影响。