The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values ​​of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥ 0.35 kUA/L. The aim of this study was to evaluate the diagnostic validity of sIgE levels to alpha-gal ≥ 0.1 kUA/L for identifying AGS. This was a cross-sectional analysis of adult patients with available data on sIgE levels to alpha-gal, classified into two groups according to the presence (Group 1) or absence (Group 2) of symptoms after being exposed to potential sources of alpha-gal. Values of sIgE to alpha-gal ≥ 0.1 kUA/l were considered a positive result. A descriptive analysis of internal and external validity parameters was performed in the entire population and adjusted by sex. The study included 33 individuals in Group 1 and 65 in Group 2, with a mean age of around 47 years. The analysis of internal validity parameters revealed a high sensitivity, specificity, and positive probability ratio, with higher sensitivity in men and higher specificity in women. The analysis of external validity parameters showed a high negative predictive value and global value in all populations and both sexes. However, the positive predictive value was relatively high in men, but low in women. Our results suggest that sIgE levels ≥ 0.1 kUA/L may be a useful tool for the diagnosis of AGS, although other factors and diagnostic techniques should also be considered.

中文翻译：

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α-gal 综合征中特定免疫球蛋白 E 水平对 α-gal 的诊断有效性：横断面分析

α-gal综合征（AGS）的诊断基于暴露于潜在α-gal来源后出现的症状以及α-gal特异性IgE（sIgE）值≥0.1 kUA/L或≥0.35夸/升。本研究的目的是评估 sIgE 水平对 α-gal ≥ 0.1 kUA/L 诊断 AGS 的有效性。这是对成年患者的横断面分析，其中包含有关 α-半乳糖 sIgE 水平的可用数据，根据暴露于潜在的 α-半乳糖来源后症状的存在（第 1 组）或不存在（第 2 组）分为两组加仑。α-gal 的 sIgE 值≥ 0.1 kUA/l 被视为阳性结果。对整个人群进行内部和外部有效性参数的描述性分析，并按性别进行调整。该研究包括第 1 组 33 名受试者和第 2 组 65 名受试者，平均年龄约为 47 岁。内部效度参数分析显示具有较高的敏感性、特异性和阳性概率比，其中男性敏感性较高，女性特异性较高。外部有效性参数的分析显示，在所有人群和性别中均具有较高的阴性预测值和全局值。然而，男性的阳性预测值相对较高，而女性的阳性预测值相对较低。我们的结果表明，sIgE 水平≥ 0.1 kUA/L 可能是诊断 AGS 的有用工具，尽管还应考虑其他因素和诊断技术。