:: 1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial property. Their precise mechanism of action is not known but it is postulated that they act by inhibiting the biosynthesis of certain prostaglandins. 1, 3, 4-oxadiazoles are a class of heterocyclic compounds with wide variety of biological and pharmacological activities. They have been reported to possess analgesic, antimicrobial, antipyretic and anti-inflammatory properties. These compounds are also active against a number of other inflammatory conditions such as arthritis, gout etc. A wide variety of these compounds have been synthesized and some of them are under clinical trials. In this review article, anti-inflammatory and antimicrobial activity of the 1, 3, 4- oxadiazole shall be discussed.

中文翻译：

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1, 3, 4-恶二唑及其衍生物的抗炎和抗菌潜力：综述

* 1,3,4-恶二唑及其衍生物具有显着的抗炎和抗菌特性。它们的确切作用机制尚不清楚，但推测它们通过抑制某些前列腺素的生物合成来起作用。1,3,4-恶二唑是一类具有多种生物和药理活性的杂环化合物。据报道，它们具有镇痛、抗菌、解热和抗炎特性。这些化合物还可以有效对抗许多其他炎症，例如关节炎、痛风等。已经合成了多种这些化合物，其中一些正在进行临床试验。在这篇综述文章中，将讨论 1,3,4-恶二唑的抗炎和抗菌活性。