: Cushing syndrome (CS), characterised by endogenous or exogenous glucocorticoid hormone excess, is associated with several systemic complications, including impaired glucose metabolism, which often becomes clinically manifest as diabetes mellitus (DM). In addition, CS can harm the arterial wall because of hyperglycaemia, dyslipidaemia, hepatic steatosis, and central obesity. These metabolic disorders promote atherosclerosis by synthesising adipokines, leptin, and proinflammatory cytokines. Lower limb arterial complications in CS are common and significantly impact morbidity and mortality. Furthermore, CS, in combination with DM, is likely to cause more diffuse vascular disease that predominantly affects distal arterial beds. In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.

中文翻译：

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内分泌失调和外周动脉疾病 - 一系列评论库欣综合征 - 皮质醇过多

：库欣综合征 (CS) 的特征是内源性或外源性糖皮质激素过多，与多种全身并发症相关，包括葡萄糖代谢受损，临床上通常表现为糖尿病 (DM)。此外，CS还可因高血糖、血脂异常、肝脂肪变性和向心性肥胖而损害动脉壁。这些代谢紊乱通过合成脂肪因子、瘦素和促炎细胞因子促进动脉粥样硬化。CS 中的下肢动脉并发症很常见，并且显着影响发病率和死亡率。此外，CS 与 DM 相结合，可能会导致更广泛的血管疾病，主要影响远端动脉床。总之，CS 通过引起动脉血管壁的功能和形态恶化并增加动脉粥样硬化的经典危险因素的存在，从而促进动脉粥样硬化，包括外周动脉疾病。