Formazans are well-known complexing agents and form highly stable complexes with verity of metals that are useful for number of pharmaceutical applications. The activity profile of formazans and their complexes are huge that include antibacterial, antifungal, antioxidant, anti-fertility, anti-tubercular, antiviral, anti-inflammatory, anticancer, anti-HIV, and anti-proliferative are among the biological activities covered by the formazans. The structures, synthesis, reactions, and spectral properties of formazans have been studied to highlight their potential applications in a variety of bioactive phenomena and analytical applications. The biological potential of the compounds will be greatly enhanced when substitution is carried out at R and R2. We observed that electron withdrawing groups at para position (if R, R1 & R2 = phenyl ring) are the best substitutions to achieve potent pharmacological activities.

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复杂偶氮化合物的合成和生物活性：甲臜及其配合物的研究进展

甲臜是众所周知的络合剂，可与多种金属形成高度稳定的络合物，可用于多种药物应用。甲臜及其复合物的活性分布广泛，包括抗菌、抗真菌、抗氧化、抗生育、抗结核、抗病毒、抗炎、抗癌、抗艾滋病毒和抗增殖等生物活性。甲臜。对甲臜的结构、合成、反应和光谱特性进行了研究，以突出其在各种生物活性现象和分析应用中的潜在应用。当R和R2发生取代时，化合物的生物潜力将大大增强。我们观察到，对位吸电子基团（如果 R、R1 和 R2 = 苯环）是实现有效药理活性的最佳取代基。