Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures.,Journal of the Pediatric Infectious Diseases Society

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Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures.
Journal of the Pediatric Infectious Diseases Society ( IF 3.2 ) Pub Date : 2023-10-28 , DOI: 10.1093/jpids/piad099
Bahaa Abu-Raya _{1,

2} , Frederic Reicherz _{1,

2,

3} , Christina Michalski _{1,

2} , Marina Viñeta Paramo _{1,

2} , Abdelilah Majdoubi _{1,

2} , Liam Golding _{1,

2} , Madison Granoski ₄ , Aleksandra Stojic ₄ , David J Marchant ₄ , Pascal M Lavoie _{1,

2}

Affiliation

Studies have linked respiratory syncytial virus (RSV) antibody-mediated phagocytosis and complement deposition to severe RSV infection in humans. This study shows waning of these antibody functions in women of childbearing age in 2020-2021 during the implementation of COVID-19 mitigation measures, in absence of RSV circulation. These functions could be explored as correlates of protection against severe RSV disease.

中文翻译：

在 COVID-19 大流行缓解措施高峰期间，呼吸道合胞病毒抗体功能丧失。

研究已将呼吸道合胞病毒 (RSV) 抗体介导的吞噬作用和补体沉积与人类严重 RSV 感染联系起来。这项研究表明，在实施 COVID-19 缓解措施期间，在没有 RSV 循环的情况下，2020-2021 年育龄妇女的这些抗体功能会减弱。这些功能可以作为预防严重 RSV 疾病的相关因素进行探索。

更新日期：2023-10-28

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