Breast cancer is the most prevalent malignant neoplasm worldwide, necessitating the development of novel therapeutic strategies owing to the limitations posed by conventional treatment modalities. Immunotherapy is an innovative approach that has demonstrated significant efficacy in modulating a patient's innate immune system to combat tumor cells. In the era of precision medicine, adoptive immunotherapy for breast cancer has garnered widespread attention as an emerging treatment strategy, primarily encompassing cellular therapies such as tumor-infiltrating lymphocyte therapy, chimeric antigen receptor T/NK/M cell therapy, T-cell receptor gene-engineered T-cell therapy, lymphokine-activated killer cell therapy, cytokine-induced killer cell therapy, natural killer cell therapy, and γδ T cell therapy, among others. This treatment paradigm is based on the principles of immune memory and antigen specificity, involving the collection, processing, and expansion of the patient's immune cells, followed by their reintroduction into the patient's body to activate the immune system and prevent tumor recurrence and metastasis. Currently, multiple clinical trials are assessing the feasibility, effectiveness, and safety of adoptive immunotherapy in breast cancer. However, this therapeutic approach faces challenges associated with tumor heterogeneity, immune evasion, and treatment safety. This review comprehensively summarizes the latest advancements in adoptive immunotherapy for breast cancer and discusses future research directions and prospects, offering valuable guidance and insights into breast cancer immunotherapy.

中文翻译：

---

乳腺癌过继细胞免疫疗法：利用免疫细胞的力量。

乳腺癌是全世界最常见的恶性肿瘤，由于传统治疗方式的局限性，需要开发新的治疗策略。免疫疗法是一种创新方法，已证明在调节患者先天免疫系统对抗肿瘤细胞方面具有显着功效。在精准医疗时代，乳腺癌过继免疫疗法作为一种新兴的治疗策略受到广泛关注，主要包括肿瘤浸润淋巴细胞疗法、嵌合抗原受体T/NK/M细胞疗法、T细胞受体基因疗法等细胞疗法。 -工程T细胞疗法、淋巴因子激活的杀伤细胞疗法、细胞因子诱导的杀伤细胞疗法、自然杀伤细胞疗法和γδT细胞疗法等。这种治疗模式基于免疫记忆和抗原特异性的原理，涉及收集、处理和扩增患者的免疫细胞，然后将其重新引入患者体内，以激活免疫系统并防止肿瘤复发和转移。目前，多项临床试验正在评估乳腺癌过继免疫疗法的可行性、有效性和安全性。然而，这种治疗方法面临与肿瘤异质性、免疫逃避和治疗安全性相关的挑战。该综述全面总结了乳腺癌过继性免疫治疗的最新进展，并讨论了未来的研究方向和前景，为乳腺癌免疫治疗提供了有价值的指导和见解。