There is no strong evidence that any specific diet is the preferred treatment for lipodystrophy syndromes. Here we remark on the benefits of a very-low calorie diet (VLCD) in a patient with familial partial lipodystrophy type 2 (FPLD2). A 38-year-old female diagnosed with FPLD2, with a history of multiple comorbidities, underwent 16 weeks of VLCD with a short-term goal of improving her metabolic state rapidly to achieve pregnancy by in-vitro fertilization (IVF). We observed a reduction of 12.3kg in body weight and 1.4% in HbA1c. The decrease in the area under the curves of insulin (-33.2%), triglycerides (-40.7%), and free fatty acids (-34%) were very remarkable. Total body fat was reduced by 16%, and liver fat by 80%. Her egg retrieval rate and quality during IVF were far superior to past hyperstimulation. Our data encourage the use of this medical approach for other patients with similar metabolic and reproductive abnormalities due to adipose tissue insufficiency.

中文翻译：

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极低热量饮食可以缓解家族性部分性脂肪营养不良症中的糖尿病和高甘油三酯血症。

没有强有力的证据表明任何特定饮食是脂肪营养不良综合征的首选治疗方法。在此，我们讨论极低热量饮食 (VLCD) 对 2 型家族性部分脂肪代谢障碍 (FPLD2) 患者的益处。一名被诊断患有 FPLD2 的 38 岁女性，有多种合并症史，接受了 16 周的 VLCD，短期目标是迅速改善代谢状态，通过体外受精 (IVF) 实现妊娠。我们观察到体重减少了 12.3 公斤，糖化血红蛋白 (HbA1c) 减少了 1.4%。胰岛素（-33.2%）、甘油三酯（-40.7%）和游离脂肪酸（-34%）的曲线下面积下降非常显着。全身脂肪减少 16%，肝脏脂肪减少 80%。她在试管受精过程中的取卵率和质量远远优于过去的过度刺激。我们的数据鼓励对其他因脂肪组织不足而具有类似代谢和生殖异常的患者使用这种医疗方法。