Background Beverage consumption was found to be associated with cardiovascular disease and mortality in the general population. However, it is unclear whether this association still exists in individuals with inflammatory bowel disease (IBD). Objectives To investigate the associations of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with cardiovascular disease and all-cause mortality among individuals with IBD. Design Prospective cohort study. Methods We included 1981 participants with IBD in the UK Biobank. Consumption of beverages was measured using a validated 24-h diet recall. Outcomes of interest were overall cardiovascular disease and all-cause mortality. Cox proportional hazard models were used to estimate the hazard ratios and 95% confidence intervals (CIs). Results During a mean (SD) follow-up of 10.1 (1.7) years, we documented 205 cardiovascular events and 133 deaths. Compared to non-consumers, those consuming sugar-sweetened beverages more than 1 unit/day (reported in glasses/cans/250 ml/cartons) were associated with 64% (95% CI: 5-155, p = 0.030) and 97% (95% CI: 16-233, p = 0.012) increased risk of cardiovascular disease and all-cause mortality, respectively. We also observed a 78% (95% CI: 3-205, p = 0.038) increased risk of cardiovascular disease in participants who consumed artificially sweetened beverages more than 1 unit/day when compared with non-consumers. We did not observe significant associations between natural juice consumption and the two outcomes in IBD. Conclusion Higher sugar- and artificially sweetened beverage consumption were associated with adverse cardiovascular and mortality outcomes in IBD. These exploratory results were consistent with the evidence in the general population and highlighted the importance of diet management in individuals with IBD.

中文翻译：

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在一项前瞻性队列研究中，含糖饮料、人工甜味饮料和天然果汁与炎症性肠病患者的心血管疾病和全因死亡率之间的关系。

背景 研究发现饮料消费与一般人群的心血管疾病和死亡率相关。然而，目前尚不清楚这种关联在炎症性肠病（IBD）患者中是否仍然存在。目的 调查含糖饮料、人工甜味饮料和天然果汁与 IBD 患者心血管疾病和全因死亡率的关系。设计前瞻性队列研究。方法 我们纳入了英国生物银行的 1981 名 IBD 参与者。使用经过验证的 24 小时饮食回忆来测量饮料的消耗量。感兴趣的结果是总体心血管疾病和全因死亡率。Cox 比例风险模型用于估计风险比和 95% 置信区间 (CI)。结果 在平均 (SD) 10.1 (1.7) 年的随访期间，我们记录了 205 起心血管事件和 133 例死亡。与非消费者相比，每天饮用含糖饮料超过 1 单位（按杯/罐/250 毫升/箱报告）的人与 64%（95% CI：5-155，p = 0.030）和 97 相关。 % (95% CI: 16-233, p = 0.012) 心血管疾病和全因死亡率风险分别增加。我们还观察到，与非消费者相比，每天饮用人工甜味剂饮料超过 1 单位的参与者患心血管疾病的风险增加了 78%（95% CI：3-205，p = 0.038）。我们没有观察到天然果汁消耗与 IBD 的两种结果之间存在显着关联。结论 摄入较高的糖和人工甜味剂饮料与 IBD 患者的不良心血管和死亡率结果相关。这些探索性结果与一般人群的证据一致，并强调了饮食管理对 IBD 患者的重要性。