Sporadic cerebral amyloid angiopathy (CAA) is a highly prevalent small vessel disease in ageing population with potential severe complications including lobar intracerebral hemorrhage (ICH), cognitive impairment, and dementia. Although diagnosis of CAA was made only with postmortem neuropathological examination a few decades ago, diagnosing CAA without pathological proof is now allowed in living patients. This review focuses on recently identified biomarkers of CAA and current diagnostic criteria.

中文翻译：

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脑淀粉样血管病的体内诊断：最新综述。

散发性脑淀粉样血管病（CAA）是一种在老龄化人群中高度流行的小血管疾病，具有潜在的严重并发症，包括脑叶出血（ICH）、认知障碍和痴呆。尽管几十年前CAA的诊断仅通过死后神经病理学检查来进行，但现在无需病理学证据即可在活体患者中诊断CAA。本综述重点关注最近发现的 CAA 生物标志物和当前的诊断标准。