BACKGROUND The mainstay of soil-transmitted helminth (STH) control is repeated mass drug administration (MDA) of anthelmintics to endemic populations. Individual longitudinal compliance treatment patterns are important for identifying pockets of infected individuals who remain untreated and serve as infection reservoirs. METHODS The Geshiyaro Project censused the study population in Wolaita, Ethiopia at baseline in 2018. Individual longitudinal compliance was recorded for six rounds of community-wide MDA (cMDA). The probability distribution of treatment frequency was analysed by age and gender stratifications. Probabilities of transmission interruption for different compliance patterns were calculated using an individual-based stochastic model of Ascaris lumbricoides transmission. RESULTS The never-treated (0.42%) population was smaller than expected from a random positive binomial distribution. The observed compliance frequency was well described by the beta-binomial distribution. Preschool-age children (odds ratio [OR] 10.1 [95% confidence interval {CI} 6.63 to 15.4]) had the highest never-treated proportion of the age groups. Conversely, school-age children (SAC) and adults (OR 1.03 [95% CI 0.98 to 1.09]) had the highest always-treated proportion of the age groups. CONCLUSIONS The study reports the largest dataset of individual longitudinal compliance to cMDA for STH control. Clear pattens are shown in the age-dependent distribution of individual compliance behaviour. The impact of compliance on the probability of elimination is significant, highlighting the importance of recording the full frequency distribution, not just the never-treated proportion.

中文翻译：

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埃塞俄比亚南部六轮社区大规模药物管理中个人对土源性蠕虫感染驱虫治疗的依从性模式。

背景 土源性蠕虫（STH）控制的主要手段是对流行人群重复大规模给药（MDA）驱虫药。个体纵向依从性治疗模式对于识别尚未得到治疗并成为感染储存库的感染者群体非常重要。方法 Geshiyaro 项目在 2018 年对埃塞俄比亚沃莱塔的研究人群进行了基线普查。记录了六轮社区范围 MDA (cMDA) 的个人纵向依从性。按年龄和性别分层分析治疗频率的概率分布。使用基于个体的蛔虫传播随机模型计算不同顺应模式的传播中断概率。结果 从未接受治疗的人群 (0.42%) 小于随机正二项分布的预期。β-二项式分布很好地描述了观察到的依从频率。学龄前儿童（比值比 [OR] 10.1 [95% 置信区间 {CI} 6.63 至 15.4]）在各年龄组中从未接受治疗的比例最高。相反，学龄儿童 (SAC) 和成人 (OR 1.03 [95% CI 0.98 至 1.09]) 在各年龄组中始终接受治疗的比例最高。结论 该研究报告了关于 STH 控制的 cMDA 个人纵向依从性的最大数据集。个人依从行为的年龄依赖性分布显示出清晰的模式。合规性对消除概率的影响是显着的，突出了记录完整频率分布的重要性，而不仅仅是从未处理过的比例。