BACKGROUND AND AIM The endocannabinoid system is a signalling system composed of endocannabinoids (eCBs), their receptors, and the enzymes involved in their synthesis and metabolism. Alterations in the ECS are linked to the development of cardiometabolic diseases. Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk factors. METHODS The study included 133 young adults (age 22.1 ± 2.2 years, 67% women). Fasting plasma levels of eCBs and their analogues were measured using liquid chromatography-tandem mass spectrometry. Body composition, brown adipose tissue (BAT) volume, glucose uptake, and traditional cardiometabolic risk factors were measured. RESULTS Plasma levels of eCBs and several eCB analogues were positively correlated with adiposity and traditional cardiometabolic risk factors (e.g., serum insulin and triacylglycerides levels, all r ≥ 0.17 and p ≤ 0.045). Plasma levels of 2-AG and PDEA were negatively correlated with BAT volume and glucose uptake (all r ≤ -0.17 and P ≤ 0.047). We observed that the plasma levels of eCBs and their analogues were higher in metabolically unhealthy overweight-obese participants than in metabolically healthy overweight-obese participants. CONCLUSION Our findings show that the plasma levels of eCBs and their analogues are related to higher levels of adiposity and worse cardiometabolic profile.

中文翻译：

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年轻人体内较高的内源性大麻素及其类似物血浆水平与较差的心脏代谢特征相关。

背景与目的内源性大麻素系统是由内源性大麻素（eCB）、其受体以及参与其合成和代谢的酶组成的信号系统。ECS 的改变与心脏代谢疾病的发展有关。在这里，我们研究了 eCB 及其类似物的血浆水平与身体成分和心脏代谢危险因素之间的关系。方法 该研究包括 133 名年轻人（年龄 22.1 ± 2.2 岁，67% 为女性）。使用液相色谱-串联质谱法测量 eCB 及其类似物的空腹血浆水平。测量了身体成分、棕色脂肪组织（BAT）体积、葡萄糖摄入量和传统心脏代谢危险因素。结果 eCB 和几种 eCB 类似物的血浆水平与肥胖和传统心脏代谢危险因素（例如血清胰岛素和三酰甘油水平，所有 r ≥ 0.17 且 p ≤ 0.045）呈正相关。2-AG 和 PDEA 的血浆水平与 BAT 体积和葡萄糖摄取呈负相关（所有 r ≤ -0.17 且 P ≤ 0.047）。我们观察到，代谢不健康的超重肥胖参与者的 eCB 及其类似物的血浆水平高于代谢健康的超重肥胖参与者。结论 我们的研究结果表明，eCB 及其类似物的血浆水平与较高的肥胖水平和较差的心脏代谢状况有关。