Chronic inflammatory skin diseases, characterized by a vicious cycle of infection and hyperinflammation, necessitate consistent and effective antimicrobial treatment of target lesions to achieve practical therapeutic outcomes. Antimicrobial dressing materials offer notable advantages over conventional therapeutic drugs, including ease of application, extended contact time, and targeted antimicrobial action, resulting in enhanced efficacy in breaking the vicious cycle. In line with these advantages, this study aims to develop a plug-and-playable recombinant adhesive protein (RAP) inspired by the adhesive properties of marine mussels, serving as a durable and effective surface functionalization strategy. By genetically recombining mussel foot protein with antimicrobial peptides, RAP effectively incorporates antimicrobial properties into biomaterials for treating chronic inflammatory skin diseases. The durable adhesion of RAP ensures long-lasting antimicrobial functionality on target surfaces, MFP making it a promising approach to inhibit chronic inflammation. In addition, when dip-coated onto cotton gauze, RAP can be utilized as an antimicrobial patch, effectively suppressing chronic inflammation through the inhibition of bacteria-induced toll-like receptor signaling. These findings underscore the potential of nature-inspired protein-based surface functionalization of biomaterials as a compelling approach to advance the treatment of chronic inflammatory skin diseases.

中文翻译：

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受贻贝启发的基于重组粘附蛋白的功能化，用于慢性炎症性皮肤病的一致有效的抗菌治疗

慢性炎症性皮肤病的特点是感染和过度炎症的恶性循环，需要对目标病变进行持续有效的抗菌治疗，以达到实际的治疗效果。与传统治疗药物相比，抗菌敷料材料具有显着优势，包括易于使用、延长接触时间和有针对性的抗菌作用，从而增强打破恶性循环的功效。根据这些优势，本研究旨在开发一种即插即用的重组粘附蛋白（RAP），其灵感来自于海洋贻贝的粘附特性，作为一种持久且有效的表面功能化策略。通过将贻贝足蛋白与抗菌肽进行基因重组，RAP 有效地将抗菌特性融入到治疗慢性炎症性皮肤病的生物材料中。 RAP 的持久粘附力确保目标表面具有持久的抗菌功能，MFP 使其成为抑制慢性炎症的一种有前途的方法。此外，当浸涂到棉纱布上时，RAP 可以用作抗菌贴剂，通过抑制细菌诱导的 Toll 样受体信号传导，有效抑制慢性炎症。这些发现强调了受自然启发的基于蛋白质的生物材料表面功能化作为促进慢性炎症性皮肤病治疗的令人信服的方法的潜力。