Here, screen-printed carbon electrodes (SPCEs) were modified with ultrafine and mainly mono-disperse sea urchin-like tungsten oxide (SUWO3) nanostructures synthesized by a simple one-pot hydrothermal method for non-enzymatic detection of dopamine (DA) and uric acid (UA) in synthetic urine. Sea urchin-like nanostructures were clearly observed in scanning electron microscope images and WO3 composition was confirmed with XRD, Raman, FTIR and UV-Vis spectrophotometer. Modification of SPCEs with SUWO3 nanostructures via the drop-casting method clearly reduced the Rct value of the electrodes, lowered the ∆Ep and enhanced the DA oxidation current due to high electrocatalytic activity. As a result, SUWO3/SPCEs enabled highly sensitive non-enzymatic detection of DA (LOD: 51.4 nM and sensitivity: 127 µA mM-1 cm-2) and UA (LOD: 253 nM and sensitivity: 55.9 µA mM-1 cm-2) at low concentration. Lastly, SUWO3/SPCEs were tested with synthetic urine, in which acceptable recoveries for both molecules (94.02-105.8%) were obtained. Given the high selectivity, the sensor has the potential to be used for highly sensitive simultaneous detection of DA and UA in real biological samples.

中文翻译：

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一种基于一锅合成氧化钨纳米结构修饰丝网印刷电极的一次性传感器，用于选择性检测多巴胺和尿酸。

在这里，丝网印刷碳电极（SPCE）用超细且主要是单分散的海胆状氧化钨（SUWO3）纳米结构进行修饰，该纳米结构通过简单的一锅水热法合成，用于多巴胺（DA）和尿酸的非酶检测合成尿中的酸（UA）。在扫描电子显微镜图像中清楚地观察到海胆状纳米结构，并通过 XRD、拉曼、FTIR 和紫外-可见分光光度计确认了 WO3 成分。通过滴铸法用 SUWO3 纳米结构对 SPCE 进行改性，明显降低了电极的 Rct 值，降低了 ΔEp，并由于高电催化活性而增强了 DA 氧化电流。因此，SUWO3/SPCE 能够对 DA（LOD：51.4 nM，灵敏度：127 µA mM-1 cm-2）和 UA（LOD：253 nM，灵敏度：55.9 µA mM-1 cm-2）进行高灵敏度非酶检测。 2）低浓度。最后，用合成尿液测试了 SUWO3/SPCE，两种分子都获得了可接受的回收率 (94.02-105.8%)。由于具有高选择性，该传感器有潜力用于高灵敏度同时检测真实生物样品中的DA和UA。